聚DL－乳酸、β－磷酸钙（PDLLA／β－TCP）膜进行了体内外降解性能研究。体外将膜置于温度为37℃、pH＝7．4的缓冲溶液中，分2、4、8、12、16用取样，进行分子量测试及SEM观察．体内选取小鼠15只，将膜同期植入小鼠皮下，分别于2、4、8、12、16周处死小鼠，切取标本，常规制片，光镜下观察。本文认为：PDLLA／β－TCP具有良好的生物相容性、可降解性及骨结合能力，膜材还具有一定的硬度和韧性，是一种很有应用前景的GTR材料。

The Biodegradation of PDLLA/β-TCP Membranin in Guided Tissue Regeneration Quan Daping; Li Shipu; Li Xiangltang; Jiang Xin; Wei Shusheng; Wang Suozhi(Dr.,Biomedical Material and Engineering Centre,WUT,Wuhan 430070,China.) The degradation and biocompatibility of PDLLA/β-TCP membranes in vitro and in vivo was studied in ihis paper. TheWw of PDLLA/β-TCP membrans decreased from 1. 92×105 to 0. 83×105 during 4 weeks in PH~ 7. 4 PBS solution at t=37 ℃ PDLLA/β-TCP membrans was implanted subcutaneously in fifteen kumin mice at the same time. the mice was killed respectively after 2、4、8、12 and 16 weeks. Histological sections of the membranes including the surrounding tissues were prepared and investigated by lightmicroscopes. The results suggested that PDLLA/β-TCP membrane would be a good biedegradable and biocompatible material to guidetissue regeneration and may open perspectives. PDLLA, β-TCP, guided tissue regeneration